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Many believed that nicotine in tobacco could encourage respiration by stimulating the heart to beat faster or that the smoke could dry up the moisture in a recently retrieved drowned person. Tobacco smoke enemas were seen as life-saving therapies that could treat anything from respiratory failure to abdominal cramps to lethargy with its warming and stimulating properties. The smoke enema proved useful in treating patients with cholera and typhoid fever. The cost of messing up a tobacco smoke enema procedure, before rectal tubes were introduced to the resuscitation kit, was an unsanitary mess

doi: Introduction Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with different clinical and pathophysiologic phenotypes

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