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Vyvanse, a stimulant, and opioids, which are depressants, have opposing effects on the central nervous system, leading to unpredictable interactions that amplify the dangers of both substances
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A human crossover study in 18 healthy adults found that a CBD-dominant brownie containing 640 mg of CBD increased exposure to a CYP3A probe drug by 56%, while a THC-dominant brownie produced no significant effect on the same enzyme
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