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Thus, at steady state, bupropion hydrochloride extended-release (SR) tablets given twice daily, and the immediate-release formulation of bupropion given 3 times daily, are essentially bioequivalent for both bupropion and the 3 quantitatively important metabolites

Given the well-established health consequences of smoking, the public health community has established and maintained a comprehensive tobacco control effort, including restrictions on smoking in worksites and other public places, increased tobacco taxation, increased access to evidence-based tobacco treatment, and public health national media campaigns [3]

Today, countries such as Italy, France, and Ireland already have at least partial bans on smoking in private cars when minors or pregnant women are present

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