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Collectively, these results indicate that the Tg(h GPR15 ) phenotype with elevated GPR15 levels could aggravate TNBS-induced colitis while offering better protection against DSS-induced ulcerative colitis under cigarette smoke exposure

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109, 110, 111 Along with the lack of evidence of efficacy in smoking cessation, an important disadvantage is the concerning level of uptake of high concentration nicotine salt products in non-smokers including young people

We might not have expected it to come out of the Amish community, but with the Amish as subjects it will certainly get more public exposure than your average research study.