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Dedifferentiated RPE had globally decreased chromatin accessibility and expression of genes linked to hallmarks of aging. Notably, young, dedifferentiated RPE also exhibited a compensatory upregulation of hallmarks of aging-related genes including mitochondrial function and proteostasis while aged dedifferentiated RPE did not, which decreased their survival following CSC treatment, as experimentally verified with TUNEL labeling

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Lacking any "suitable evidence that the ancient, indigenous people utilized Cannabis for food, oil, or fiber", they concluded "the deceased was more concerned with the intoxicant and/or medicinal value of the Cannabis remains." [19] The Chinese archaeologist Hongen Jiang and his colleagues excavated a circa 2,400-2,800 BP tomb in northwest China's Turpan Basin and found the remains of an approximately 35-year-old man with Caucasian features who had been buried with thirteen 1-meter cannabis plants, placed diagonally across his chest