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This is what's called combination therapy

The longer you smoke, the higher your risk of serious illnesses that include: Cancers such as lung, throat, stomach, liver and colorectal Stroke Respiratory disease Cardiac disease Cataracts and macular degeneration Damaged gums and teeth, sometimes including tooth loss Rheumatoid arthritis Peptic ulcers Type 2 diabetes In men: erectile dysfunction, reduced fertility and increased risk of birth defects in offspring In women: lower bone density, which can lead to hip and other fractures

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Even one puff will cause your blood vessels to shrink