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Abstract This is a pilot examination of the hypothesis that some of the effects of smoking cigarettes in humans are mediated through nicotine activation of opioid and dopamine (DA) neurotransmission

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5 There are various methods for smoking cessation, including behavior modification (e.g., counseling, hypnosis), alternative therapies (e.g., acupuncture), nicotine replacement products (e.g., nicotine spray, gum, inhaler, lozenge, and patch), medications (e.g., bupropion, varenicline), and the latest interventionbattery-operated electronic cigarettes (e-cigarettes)

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