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London: National Institute of Clinical Excellence

PA can be further oxidized by xanthine oxidase (XO) to form 5-hydroxy-pyrazinoic acid (5-OH-PA), a metabolite thought to be more hepatotoxic than PA

About half were ignored as they were clearly not relevant to the current review based on their title or they were duplicates

for people who smoke in countries where some or all alternatives are banned, knowing whats safer doesnt help if you can only get it on the black market (which in turn also makes it less safe) While the problem is global, the cost-effectiveness of better risk communication may vary among different populations - for example, doctors may find it easier to understand the risk continuum concept and have more opportunity to disseminate it More in-depth analyses of these and other questions would be critical in helping funders interested in global health determine how it stacks up against other efforts when considering it as an impactful cause area.