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"People who smoke are more likely to have deterioration in gray and white matter, which provides a possible explanation as to why 14% of global Alzheimer's disease cases could be attributable to cigarette smoking," the study states

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Emax030 AUEC - Area under the effect curve (smoking urge change-from-baseline) from 30 to 90 min

The dose is lower and slower than a cigarette, which helps reduce withdrawal while you break the behavioral part of smoking