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Based on self-reported smoking behavior from NHSP questionnaires, we extracted age at smoking initiation, cumulative smoking exposure (in pack-years, PY), and status as former or current smoker

Puff gently, recheck, and then move on to Step 5

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This variation between studies may be due to the different puff routines used to generate the tobacco smoke (HCI vs ISO), aging of smoke particles over the puff routine (4 vs 8 mins) and dilution ratios in the smoke bags (75 vs 33)