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Tobacco addiction is a complex issue that often requires a multifaceted approach to treatment

Nicotine activates the brain to release dopamine, a chemical that signals pleasure

* Correspondence: Francisco Novoa-Muoz, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

We had 81.5%, 92.9%, and 84.6% reviewer concordance during title/abstract screening and 88.9%, 94.4%, and 97.7% reviewer concordance for full-text screening of studies on head and neck cancers, stroke, and ischemic heart disease, respectively