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Research suggests smokers, of more than 20 cigarettes a day, are three-times more likely to wrinkle prematurely than non-smokers, and the effect is more pronounced in women than in men

Warnecke, R

Observing heterogenous exposure definitions, we also evaluated the impact of omitting observations that used ever-chewing tobacco as the exposure group, keeping only observations that compared current tobacco chewers to nontobacco chewers, and the impact of potential regional differences in chewing tobacco definitions by restricting data to only that from Asian countries, the region with the highest number of chewing tobacco users

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