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To further address the challenges of disease stratification and mechanistic heterogeneity, cutting-edge technologies such as single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, artificial intelligence algorithms, and integrative multi-omics analysis have enabled the high-resolution identification of key cellular populations and molecular markers that are closely associated with disease severity and therapeutic response (189, 193195)

[3] [8] It has reportedly spread to Europe, India and other regions via immigration, tourism and trade

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