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FDA) has stated on several occasions that switching to new tobacco and nicotine-containing products that reduce the exposure of adults who smoke to Harmful and Potentially Harmful Constituents (HPHCs) such as tobacco-specific nitrosamines ( N -nitrosonornicotine [NNN] and Nicotine-Derived Nitrosamine Ketone [NNK]) may reduce the harm associated with smoking [9]

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Along with inflammation, epithelial to mesenchymal transition have been reported in people who smoke and patients with COPD, which may be one of the shared mechanisms leading to lung cancer in these patients [87,88,89,90,91]