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Concern about severe psychiatric and cardiac side effects have been studied through US Food and Drug Administration post-marketing randomised control trials (RCTs)

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Materials and methods Study population Individuals were selected from the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort

Research also indicates that consumers who reduced their smoking by more than 3 packs of cigarettes per month were much less likely to realize health gains