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Larry Bucshon, R-Ind., wrote to Health and Human Services Secretary Xavier Becerra to encourage more focus on bringing new pharmaceutical cessation therapies to market

The clinical significance of this is unclear

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Ledgerwood claims that because the initial hit of pleasure from cigarette smoking is felt almost instantly but quickly wears off, smokers use tobacco frequently to get the same stimulant experience. According to Bernard Le Foll, Chair of Addiction Psychiatry in the Department of Psychiatry at the University of Toronto, Tobacco addiction is primarily described as a lack of control on the use of a substance and ongoing use notwithstanding the consequences. People who get addicted to a substance will go through cravings and/or withdrawal symptoms if they stop using it for a while