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Eleven RCTs selected through a systematic search and screening172, 330, 331, 345, 346, 347, 348, 349, 350, 351, 352 and five identified through supplementary searches332, 333, 334, 353, 354 were included for synthesis

Thus, both electronic cigarettes with and without nicotine should be covered by national legislation to avoid renormalisation, as well as all existing, potential and future devices with and without nicotine, all electronic nicotine delivery systems and all refill cartridges

Peer pressure, environmental influences, and the desire to fit in can further contribute to nicotine use

Conclusions and Relevance These findings suggest that co-occurring maternal use of cannabis and nicotine products in pregnancy is associated with an increased risk of infant and neonatal death and maternal and neonatal morbidity compared with use of either substance alone