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Therefore, on December 10, 1948, when the UN General Assembly approved the Universal Declaration of Human Rights in reaction to the horrific events of WWII, highlighting that every human being is born with inherent freedom and equality, deserving of respect and worth

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Interestingly, by inhibiting SIRT6, nicotine downregulates the pro-apoptotic TNF pathway and activates the pro-survival AKT signaling, which ultimately promotes neuron survival in PD [223]

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