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The risk of progressing from controlled use of psychoactive drugs to compulsive and uncontrolled drug-use behaviors that characterize addiction is especially high in individuals who have pre- and/or co-morbid pathology, such as the presence of psychiatric disorders like depression, anxiety, and obsessive-compulsive disorder, according to a 2015 article by Christian P

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Behind its own toxicity, nicotine is a direct indicator that smoking took place, and other toxic components of tobacco smoke can be present in the air, mostly Polynuclear Aromatic Hydrocarbons and other carcinogenic compounds