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Varenicline is not suitable for everyone, including people who: have a history of mental health conditions are pregnant or nursing have severe kidney conditions have a history of seizures or other neurological conditions take certain medications, including anticonvulsants, antibiotics, and antidepressants In June 2021, Pfizer halted production of Chantix due to the presence of high levels of nitrosamines

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While nicotine doesnt yield these effects, regular consumption of this chemical can cause addiction without causing a high due to its associated effects