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Research has shown that endocannabinoids have a very important role in the female reproductive system, and that impairment of the ECS can harm the functioning of female reproductive organs and increase infertility 6

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Adverse Reactions/Side Effects The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling: Serious cardiovascular events and stroke [see Boxed Warning and Warnings and Precautions (5.1)] Vascular events [see Warnings and Precautions (5.1)] Liver disease [see Warnings and Precautions (5.2)] Adverse reactions commonly reported by COC users: Irregular uterine bleeding Nausea Breast tenderness Headache 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice