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PREPs were defined as products that substantially reduce exposure to one or more tobacco smoke toxicants as compared to exposures resulting from traditional tobacco products, and, that as a result, might be reasonably expected to reduce the risk of one or more specific diseases or other adverse health effects as compared to the risks associated with use of traditional tobacco products

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In addition, the abundance of Prevotella and Saccharibacteria (TM7) (G-1) was also positively correlated with serum IFN-, IL-10, IL-12p70, IL-13, IL-1, IL-2, IL-4 and TNF- levels of e-cigarette smokers

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