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Experimental studies in Wistar rats treated with PZA or PA showed hepatotoxicity, as demonstrated by elevated serum alanine aminotransferase, aspartate transaminase, and galactose single-point levels (Tostmann et al., 2008

These proteins regulate a spectrum of cellular functions including apoptosis, inflammation, proliferation, differentiation, and stress pathways 10 , 11 , 12 , 13

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