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Each hit of nicotine floods the brains receptor sites, overstimulating them until the neurons adapt by making more of those receptors and reducing their sensitivitya process known as upregulation

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95% CI, 1.34-2.04), cigarette smoking (aOR = 1.52

In the following graph, you can also see there has been a substantial decrease in the number of people who had to take lung medication after switching to ecigs: Read the results of Farsalinos' survey for the full data