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For example, San Marcos, California , recently passed an ordinance requiring any shop that sells tobacco products, including e-cigarettes and related devices, to purchase a city-issued tobacco retail license. The city partnered with the San Marcos Prevention Coalition and the Vista Community Clinic, which conducted surveys of local e-cigarette retailers and vape shops and determined that a number of businesses were selling these products to minors in violation of state law

In murine models, short smoke exposure has been shown to amplify dendritic cell-mediated transport of house dust mite allergens to the intrathoracic lymph nodes and to generate a local T-helper cell type 2 response

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The cumulative value of these programs often exceeds individual sample offers, with regular participants receiving multiple free products annually through points accumulation