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We found that, due to small numbers of studies, inconsistency in the data, small effect sizes or a combination of these reasons, seven outcomes for which some previous research had found an association with smoking did notunder our meta-analytic framework and conservative approach to interpreting the datahave evidence of an association

So, for the time being, they remain just that: estimates

Conversely, CD patients develop antibodies against bacterial antigens, suggesting a humoral response triggered primarily by impaired intestinal barrier function and, therefore, an increased interaction with the gut microbiota (48)

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