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[386] Humphries said that he is "one of America's finest post-Dylan singer-songwriters" and, along with Edward Hopper, "one of the two great depicters of American isolation." [387] Hoskyns called him "as important an American artist as anyone the twentieth century has produced." [388] [389] He notes that by the end of the twentieth century, "Waits was an iconic alternative figure, not just to the fans who'd grown up with him but to subsequent generations of music geeks", [390] coming to be "universally acknowledged as an elder statesman of 'alternative' rock." [391] Karen Schoemer of Newsweek said that "to the postboomer generation, he's more Dylan than Dylan

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The THC then travels to the brain and other organ systems throughout the body