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Specific health impacts include: Lung disease (chronic bronchitis, COPD, lung cancer) Heart disease and stroke commercial tobacco doubles the risk Diabetes complications smoking worsens insulin resistance Pregnancy complications , including low birth weight and stillbirth Increased risk of COVID-19 severity , especially among elders and those with comorbidities Source: U.S

Systemic administration of CLP290 (10 mg/kg, i.p.) or vehicle (20% -cyclodextrin) occurred 45 min prior to diazepam intake sessions over three non-consecutive days (Thomas et al., 2018)