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One recent study found a significant impact of long-term exposure to e-cigarette aerosol on nicotine levels and nicotine-related gene expression in the mouse brain compared to air (no comparison to smoke), highlighting the importance of determining the potential risks associated with continued use of nicotine over time [38]

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Best Budget-Friendly Choice: NKD 100 Max Brand : NKD 100 Key Features : 10ml e-liquid capacity Compact and pocket-friendly design Nicotine salt formulation Pros : Affordable pricing Smooth throat hit Wide flavor selection Cons : Limited to 4,500 puffs Price Range : $5$7 Best Suited For : Budget-conscious beginners wanting quality and convenience

it did not have a contract at the time of the study