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J Diet Suppl 21:112 Chappell AJ, Allwood DM, Johns R, Brown S, Sultana K, Anand A et al (2018b) Citrulline malate supplementation does not improve german volume training performance or reduce muscle soreness in moderately trained males and females

In addition, metformin improved the downregulation of genes associated with steroid production in diabetic male mice, resulting in increased serum and testicular testosterone levels, increased Leydig cell count, improved sperm parameters, and reduced sperm nuclear DNA fragmentation (Nna et al

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In addition to the PERK-ATF4-CHOP axis, other key ER stress pathways, such as IRE1/XBP1 and ATF6 also contribute to the UPR, collectively managing protein misfolding and restoring homeostasis, or, if stress persists, trigger cell death (Tabas and Ron, 2011)