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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels

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By the end of the first month, subtle weight changes may become visible, often accompanied by better portion control and improved energy levels

It evaluated whether retatrutide could simultaneously induce weight loss and reduce joint pain