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L., Schroeder, M

Genomic sections displaying sequence conservation over time within a single viral species or evolutionary conservation between members of the coronavirus family despite high mutation rates are indicative of essential regions of the viral genome that are functionally constrained, such as the fusion peptide within the spike S2 region [68, 69]

Specifically, lactylation of Tufm at K286 impedes its interaction with Tomm40 on mitochondria, thereby inhibiting the mitochondrial localization of Tufm and Tufm-mediated mitophagy in injured neurons

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