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By 8-12 weeks, the majority of patients who initially experienced gastrointestinal symptoms find them minimal or absent

10.1097/MPA.0b013e318214812b 60 SilvaM

It does not disrupt the interaction between dimers in the glutaminase tetramer but binds to the hydrophobic pocket between the monomer-monomer interface of the GAC, located at the junction where the N-terminal and C-terminal of the enzyme meet the catalytic domain, thereby preventing the GAC from activating conformational changes (Wilson et al., 2013

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