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Thus, future research should focus on developing diagnostic models based on genetic variations to predict HAPE susceptibility as accurately as possible

3.2 Gastrointestinal barriers The intestinal epithelium is a single layer of cells lined the gut lumen that acts as a barrier to prevent injurious, intraluminal entities as well as microorganisms, toxins, foreign antigens, and allowing the translocation of essential electrolytes, dietary nutrients, and water from lumen into the circulation [16, 51, 72]

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Collectively, regardless of disease status, this cohort of children from a konzo-affected region show signs of protein malnourishment, harbor measures of mitochondrial distress, and deficiencies in a key sulfur-containing amino acid (Cystine)