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The jury is still out on whether the prevalence of T2DM or other obesity-associated complications in PWS is lower than in general obesity

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Introduction The gluco-regulatory actions of the glucagon-like peptide-1 (GLP-1) and its related therapeutic mimetics include enhancement of glucose-dependent insulin secretion and suppression of glucagon release from pancreatic islets, as well as a decrease in postprandial glucose excursion by delay of gastric emptying and centrally-mediated effects on satiety and energy metabolism [1], [2]

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