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Subject 6969 had one sample excluded from subsequent analysis because its Lm measurement was an outlier (more than three times the interquartile range of the distribution of Lm measurements in all cores from all lungs examined)

For instance, the addition of ganitumab, a monoclonal antibody targeting IGF-1R, to carboplatin/paclitaxel chemotherapy in patients with primary epithelial ovarian cancer did not improve progression-free survival in a phase II multicenter controlled trial (65), despite the promising results of IGF-1R inhibition in various preclinical studies (25, 32, 64)

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