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DOI: 10.3390/ijms222212269

Quieting Neuroinflammation Beyond energy metabolism, both pathways converge on neuroinflammation, the activation of the brain's resident immune cells, known as microglia, in response to stress, injury, or metabolic disruption

Pathways enriched for DEGs selected from Gipr fl/fl vehicle versus Gipr Syn/ vehicle, as well as Gipr fl/fl vehicle versus Gipr fl/fl mGIPR-Ab/P1 comparisons, demonstrated that reduction of CNS GIPR function through either pharmacological or genetic intervention led to downregulation within adipose tissue of key canonical genes within these pathways (Fig

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