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They are not approved by the FDA for human use outside of clinical trials and are not legally sold as dietary supplements or over-the-counter drugs

This mechanism is one reason it has become a topic of interest in metabolic research

Some providers recommend thyroid function and liver/kidney screening

This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer