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One major concern is that chronic use of GLP-1 RAs may create a supraphysiological state of GLP-1, leading to gastrointestinal upset, pancreatitis, or excessive stimulation of pancreatic activity

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Early results from preclinical and clinical studies have shown the potential benefits of GLP-1RAs in improving glycaemic control, weight management, endothelial function, atherosclerotic plaque stability, systemic inflammation, renal function, BP levels and AF risk

Patients should remember that while diarrhea ranks among the most common Ozempic side effects, its impact varies significantly between individuals