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IGF-1/PI3K/Akt signaling stimulates the rate of protein synthesis via p70S6Kinase and p90 ribosomal S6 kinase and negatively regulates protein degradation, predominantly by its inhibiting effect on proteasomal and lysosomal protein degradation

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Regulation by non-coding RNAs Non-coding RNAs (ncRNAs) are functional RNA molecules classified into distinct types based on length and structure, including microRNAs (miRNAs) [121], long non-coding RNAs (lncRNAs) [122], circular RNAs (circRNAs) [123], transfer RNAs (tRNAs) [124], and ribosomal RNAs (rRNAs) [125]