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2Limit processed foods and added sugars Processed foods and added sugars are often high in calories and low in nutrients

Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells

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Peripheral IR primarily involves reduced insulin-mediated glucose uptake by skeletal muscle and adipose tissue, driven by defects in the insulin receptor substrate and downstream signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), leading to diminished translocation of glucose transporter type 4 (SLC2A4/GLUT4) and glucose uptake [5]