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GLP-1 receptor agonists may be appropriate second-line agents after metformin or even first-line in patients with established cardiovascular disease, chronic kidney disease, or when weight management is a priority

Turner, P

Oral semaglutide was superior to placebo and other antihyperglycemic drugs, such as iDPP4 (sitagliptin), iSGLT2 (empagliflozin) or other arGLP-1 (liraglutide) in reducing HbA1c or weight.116 Oral semaglutide was well tolerated, with a safety profile similar to that of other arGLP-1 s

These findings supported the notion that ER depletion induces ferroptosis and inhibits the growth of ER+ breast cancer cells in part through downregulation of SLC7A11 and SLC3A2