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TM packing induced by G s coupling Superimposition of the ligand-free and peptide-bound structures shows that the intracellular half of TMD aligns well, while the extracellular half is structurally divergent and exhibits a receptor-specific conformation in the absence of ligand (Fig

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Zepbound (tirzepatide) is a popular alternative because it belongs to a similar drug class (GIP/GLP-1 receptor agonist) but headache is not listed as a common side effect in its clinical trials

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