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Abbreviations BBC: Boston Birth Cohort BMC: Boston Medical Center CpG: 5-Cytosine-phosphate-guanine-3 CYP2E1: Cytochrome p450 family 2 subfamily e member 1 CV: Coefficient of variation DNA: Deoxyribonucleic acid DNAm: DNA methylation DNMT3A: DNA methyltransferase 3 alpha DNMT3B: DNA methyltransferase 3 beta ENCODE: Encyclopedia of DNA elements EWAS: Epigenome-wide association study FDR: False discovery rate GSH: Glutathione HELLP: Hemolysis, elevated liver enzymes and low platelets SD: Standard deviation LC-MS: Liquid chromatography-tandem mass spectrometry NAPQI: N -acetyl- p -benzoquinone imine SVA: Surrogate variable analysis TET1: Ten-eleven translocation methylcytosine dioxygenase 1 References Werler MM, Mitchell AA, Hernandez-Diaz S, Honein MA

27 In cases of T2D, which is a chronic condition, this mechanism can be crucial as enhanced and unregulated hepatic glucose release is a prominent pathophysiological mechanism, and controlling it can improve the prognosis of the disease to a large extent