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Nevertheless, cystine is taken up by some cells (i.e., endothelial cells) and, given the high reducing conditions, is intracellularly reduced to cysteine, employed for the synthesis of GSH (10, 11)

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MicroRNAs such as miR-214-3p and miR-15a-3p bind to the 3 untranslated region of GPX4 mRNA and suppress its translation, sensitizing cells to ferroptosis

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