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Migraine has a significant genetic component, with heritability estimates ranging from 50 to 80% (Yeh et al., 2024

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In some embodiments, the amount of thickening agent (e.g., a gelling agent) in any formulation described herein is about 0.01%, about 0.02%, about 0.03%, about 0.04%, about 0.05%, about 0.06%, about 0.07%, about 0.08%, about 0.09%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 5%, about 10%, or about 15% of the total weight of the formulation

FOXO isoforms and longevity FOXOs have emerged as longevity genes based on evidence from animal models including Hydra, C elegans, Drosophila, and mice [36]