whats the difference between glp 1 and glp 2 GLP1 Receptor Agonists vs SGLT2-I in Preventing CKD in T2DM: An Interview – AJKD Blog 110- GLP-1- Miracle or Mirage?

In the L-lactyl-CoA route, nuclear phosphorylated acetyl-CoA synthetase 2 (ACSS2) acts as a lactyl-CoA synthetase (L-lactate + CoA + ATP L-lactyl-CoA + AMP + PPi), couples physically with the GCN5-related N-acetyltransferase (GNAT) acetyl-transferase lysine acetyltransferase 2 A (KAT2A) and feeds a high-energy thio-ester directly into the catalytic pocket, driving installation of H3K18la and H3K23la and boosting Wnt and PD-L1 transcription to promote immune evasion [41]

suis most likely occurs through contact between pigs and humans 1,11

GLP-1 supplements contain various ingredients that are claimed to either stimulate your body's own L-cells in the gut to produce more GLP-1 or to indirectly mimic some of the effects of this powerful hormone

Some studies suggest improvements in structural preservation and functional outcomes, though the mechanisms remain under investigation