This also significantly elevated pro-inflammatory factors IL-6, TNF-, and IL-1 in the cerebrospinal fluid, and upregulated lipoxygenase (LOX), PTGS2, IL-6, and TNF- expression in microglial cells, which further promote inflammatory activation
For example, non-obese healthy people can metabolize lipids and glucose efficiently, so the immunomodulatory effect is reflected in immune cell subset migration, lower inflammatory factors, upregulation of circadian rhythmrelated gene expression, and greater microbial diversity
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