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Notably, in the condition of excess hemin exposure and hypoxia, our findings suggest an important contribution of the TSS pathway and its regulation by DMF for de novo cysteine synthesis and GSH generation in protecting against the oxidative and ferroptotic stresses in SCD erythroblasts

vi) 100 g/kg/min BQ-788 (i.v.) followed by 100 mol/kg berberine and 100 mol/kg atorvastatin for 1 month (i.v.)

For ferroptosis-related genes, TFRC and SLC3A2 changed significantly in the 35 years group, while TFRC, GPX4, NCOA4, and SLC3A2 changed in the 38 years group (Fig

The therapeutic potential of FOXO4-DRI was then explored