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Supplementation of anti-oxidant preparations, which include vitamin C, N-acetyl-L-cysteine, -tocopherol, methylcobalamin, and carnosine, has been widely evaluated in both pre-clinical and clinical studies, and encouraging results have been obtained from these studies [96]

The various causes of CKD in diabetic patients include diabetic nephropathy (DN), ischemic kidney disease associated with vascular disease, nephrosclerosis due to hypertension, and kidney disease unrelated to diabetes (4)

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Targeting aging with rapamycin and its derivatives in humans: a systematic review